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Similarly to other investigations the present study found th
2021-03-25
Similarly to other investigations, the present study found that ZEA in high concentrations decreases viability of both normal (Liu et al., 2018, Zheng et al., 2018a, Zheng et al., 2018b) and cancer retinoid x receptor (Khosrokhavar et al., 2009, Kowalska et al., 2017). The toxic effect of ZEA obser
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To our knowledge immunohistochemical analysis for proGRP was
2021-03-25
To our knowledge, immunohistochemical analysis for proGRP was done in 5 cases [9], [10], [17], [18]. Takagi-Takahashi et al. reported that the tumor dna ligase were positive for proGRP in one case [9]. Yamaguchi et al. also showed that tumor cells in two patients of ES/PNET with elevated serum proG
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Within the X CX PX RX motif of several prokaryotic
2021-03-25
Within the X1CX3PX5RX7 motif of several prokaryotic FGE substrates, the residues of X3, X5, and X7 are variably found as mixtures of alanine, glycine, threonine, or serine residues [26], [27]. The docked model of our identified HCTPRRP motif revealed that position X1 (H1) and position X7 (P7) were n
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br O GlcNAcase Human OGA is a multidomain protein with
2021-03-25
O-GlcNAcase Human OGA is a multidomain protein with an N-terminal domain similar to glycoside hydrolase family 84 (GH84) enzymes, a stalk domain, a C-terminal pseudo histone acetyltransferase (HAT) domain, and several low-complexity regions (Figure 1f) [43]. A splice variant that lacks the HAT do
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In the present study BACH
2021-03-25
In the present study, BACH1 downregulation did not correlate with nuclear accumulation of NRF2, suggesting that these changes were triggered via an independent mechanism. BACH1 is a transcriptional repressor that is regulated by heme. Heme binding to the BACH1 C-terminal domain inhibits BACH1 DNA bi
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br RING dimerization RING type domains are found in many
2021-03-25
RING dimerization RING-type domains are found in many different structural contexts. While many exist as single-chain Bax inhibitor peptide V5 (Fig. 3A), a notable feature of RING-type E3s is their tendency to form homodimers and heterodimers (Fig. 3C–F). Homodimeric RING-type E3s include cIAP,
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Retapamulin br Restenosis after angioplasty remains a remark
2021-03-25
Restenosis after angioplasty remains a remarkable challenge, although drug-eluting stents have reduced the incidence of restenosis considerably . Vascular smooth muscle Retapamulin (VSMCs) play a pivotal role in the development of intimal thickening and restenosis. VSMCs proliferate and migrate fr
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br A brief introduction to
2021-03-25
A brief introduction to DUBs The reversal of ubiquitin conjugation of targeted proteins relies on deubiquitinating sulconazole (DUBs), which catalytically cleave single Ub or poly-ubiquitin chains from proteins. The human genome encodes approximately 100 potential DUBs which can be classified int
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During the past three decades platinum based
2021-03-25
During the past three decades, platinum-based DNA-alkylating agents have been employed in the treatment of various cancers [14]. Oxaliplatin is currently used as a first-line treatment for colorectal cancer (CRC) [15]. Unfortunately, a large portion of CRC patients receiving oxaliplatin-based chemot
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br Conclusion Determining whether the multiple putative alga
2021-03-25
Conclusion Determining whether the multiple putative algal DGAT isoforms are functional DGATs via biochemical assays will be vital in our effort to genetically engineer algae to produce TAG on a large enough scale to make biodiesel production viable. As can be seen in O. tauri, it is possible tha
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br Experimental procedures br Introduction Protein kinases
2021-03-25
Experimental procedures Introduction Protein kinases represent one of the largest enzyme Amikacin synthesis in the human genome and act as signaling mediators in a variety of cellular processes (Manning et al., 2002). Because many diseases are associated with aberrant protein kinase activity,
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br Acknowledgements This work was supported by grants
2021-03-25
Acknowledgements This work was supported by grants from Agence Nationale de la Recherche (ANR CAPHE) and from Ligue contre le Cancer. We acknowledge the continuous support of CNRS and the University of Strasbourg. We thank the technical assistance of the “Plateforme de Chimie Intégrative de Stras
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LTD and LTC cause contraction in the rat stomach and
2021-03-25
LTD4 and LTC4 cause contraction in the rat stomach and these contractions are sensitive to CysLT1 receptor antagonists (Goldenberg and Subers, 1983, Miura et al., 1992, Miyata et al., 1995). However, effects of other leukotrienes in the gastric contraction and inhibitory effects of potent, selective
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DNA methylation is a relatively stable but
2021-03-25
DNA methylation is a relatively stable but reversible epigenetic mechanism that can regulate gene expression, and occurs at the three different cytosine sequence contexts (CG, CHG, and CHH, where H is C, A, or T) in plants [15]. Many studies suggest that DNA methylation status of genes influence pla
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Ramos cell http www apexbt com media
2021-03-25
Ramos cells carry a non-functional p53 and constitutively express the transcription factor, NF-κB (Nazari et al., 2011, Zand et al., 2008). There is much evidence to support the conclusion that the interruption of NF-κB activation promotes apoptosis in several hematological malignancies (Fabre et al
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