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Kuo et al Have shown that DAPK
2021-07-19
Kuo et al. (2006) Have shown that DAPK1 function in inhibiting microtubule (MT) assembly is through the activation of microtubule affinity-regulating kinases (MARK)/PAR-1 family kinases MARK1/2, which destabilize MT by phosphorylating tau and related MAP2/4. This relation with DAPK1 has demonstrated
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Chemokines act as ligands for
2021-07-19
Chemokines act as ligands for the chemokine receptors, which possess 7-transmembran domain-type proteins functionally coupled to G proteins. Leukocytes express 19 chemokine receptors which control their influx and activation at the site of inflammation. Human neutrophils express both CXCR-1 and CXCR
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Protein kinase casein kinase CK comprises a family of highly
2021-07-19
Protein kinase casein kinase 1 (CK1) comprises a family of highly related, constitutively active serine/threonine protein kinases (reviewed by [15]). CK1 is involved in controlling a wide variety of different cellular events including protein turnover [16], [17], nuclear import [18] and the cellular
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The results of physical parameters of the prepared
2021-07-19
The results of physical parameters of the prepared samples are summarized in Table 2. The equivalent diameter ranged from 1.09 to 1.14 mm, which is within the required size distribution of 0.8–1.25 mm. A slight increase in size is probably caused by increasing the thickness of the second coat. To d
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Patients and methods This study was performed at
2021-07-19
Patients and methods This study was performed at 3 academic centers (Chung-Ang University YongSan Hospital, Soonchunhyang University Hospital, and Chung-Ang University Hospital) in Seoul, Korea, from November 2008 to November 2010. The study protocol was approved by the institutional review boards
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PI K is a lipid kinase and generates phosphatidylinositol
2021-07-19
PI3K is a lipid kinase and generates phosphatidylinositol-(3,4,5)-trisphosphate, which is a second messenger critical for the translocation of Akt to the cytoplasmic membrane. The phosphorylation of Ser473 Akt is important in the cell survival by regulating the eNOS among other targets (Dimmeler et
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Introduction CYP is a superfamily of
2021-07-19
Introduction CYP450 is a superfamily of heme-containing monooxygenases, many of which are expressed in the liver, and they are significant phase-I SB 216763 in drug metabolism and detoxification. There are three subfamilies (CYP1, CYP2 and CYP3) that are mainly involved in the metabolism of drugs i
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In conclusion we have shown that the cellular effects produc
2021-07-17
In conclusion, we have shown that the cellular effects produced by SFN in NSCLC AZD6738 are largely mediated by SFN-induced production of ROS. Cells with higher levels of EGFR were more resistant to SFN treatment and showed resistance to SFN-induced apoptosis, suggesting that high EGFR levels prote
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The number of DBH alleles affects dopamine and norepinephrin
2021-07-17
The number of DBH Decoquinate synthesis affects dopamine and norepinephrine levels in the prefrontal cortex of mice when they are treated with disulfiram (33). Disulfiram increased dopamine and decreased norepinephrine levels in their prefrontal cortex of mice with two normal alleles, whereas disul
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Tenatoprazole To date many studies have reported
2021-07-17
To date, many studies have reported significant aberrant methylation patterns in TIMPs in various types of cancer Tenatoprazole [[16], [17], [18]]. However, little has been reported on the events that lead to the methylation of TIMPs in the UV-irradiated human skin. Therefore, the objective of this
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br Expression of DNMTs during
2021-07-17
Expression of DNMTs during testicular development In most multicellular organisms, male and female germ cells are the origin of development of an organism, and they provide inheritance of genetic and epigenetic information across the generations. Primordial germ cells (PGCs) derive from a subset
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br Materials and methods br Statistical analysis All
2021-07-17
Materials and methods Statistical analysis All statistical analyses were performed using SPSS software version 20. Protein someone’s name data of DNMTs and clinicopathological parameters were collected. Mann-Whitney U Test was used to assess the differential expression of nonparametric data o
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br Enzymes repairing alkylated DNA br Induction
2021-07-17
Enzymes repairing alkylated DNA Induction of the Ada regulon Methylated Ada is a strong activator for ada and alkA promoters. Although much weaker than the methylated form, unmethylated Ada acts alone as an activator for ada and alkA promoters. In contrast, the unmethylated protein present in
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RDH belongs to C family
2021-07-17
RDH10 belongs to 16C family of the short-chain dehydrogenase/reductase (SDRs) superfamily of proteins [12], [13]. Notably, in human genome adjacent to the gene encoding RDH10 on chromosome 8 are located two other genes encoding members of the SDR16C family: retinol dehydrogenase epidermal 2 (RDHE2,
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As a basis for the DDR substrate identification approach
2021-07-17
As a basis for the DDR1 substrate identification approach detailed below, we first set out to perform 2D-gel electrophoresis with lysates isolated from collagen-stimulated human breast cancer MDA-MB-231 Amidepsine A overexpressing DDR1 (b-isoform). This allowed us to determine whether DDR1 is not on
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