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In a previous study M ykkynen et al
2021-11-02
In a previous study (Möykkynen et al., 2003), we reported that ethanol lengthens the time needed for the AMPA receptors to recovery from desensitization in isolated hippocampal neurons. Here, we did not observe any effect of ethanol on recovery from desensitization in recombinant homomeric GluR-D re
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br Introduction Major depressive disorder MDD is a disease w
2021-11-02
Introduction Major depressive disorder (MDD) is a disease with poorly recognized etiology. Currently used antidepressant drugs, which mainly affect synaptic neurotransmitter levels, show full clinical efficacy in only one third of patients (Rush, 2007). Thus it is now generally accepted that the
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Cyclophosphamide In Solloway and colleagues reported that mi
2021-11-02
In 2015, Solloway and colleagues reported that mice with alpha cell hyperplasia due to inactive hepatic glucagon receptor signaling may most likely be caused by amino Cyclophosphamide dependent mechanisms [11]. The authors then showed these adaptations are regulated by ‘mechanistic target of rapamyc
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The GAL also modified HT system Millon et al
2021-11-02
The GAL(1–15) also modified 5-HT system (Millon et al., 2015). Using a rat medullary raphe-derived cell line RN33B, we observed that GAL(1–15) significantly decreased the 5-HT immunoreactivity in the RN33B statins hmg coa reductase inhibitors (p Conclusion All these data emphasized the role of GA
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Lenvatinib is an orally available multi targeted tyrosine ki
2021-11-02
Lenvatinib is an orally available, multi-targeted tyrosine kinase inhibitor against VEGFR1–3, FGFR1–4, PDGFRα, RET, and KIT [11,12]. In a recent phase III trial for patients with previously untreated uHCC (REFLECT study), lenvatinib showed statistical non-inferiority of overall survival compared to
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Efaproxiral Sodium Hyperactivation of Notch pathway can give
2021-11-01
Hyperactivation of Notch1 pathway can give rise to transformation into T-ALL in murine models. In more than 50% of acute T-cell lymphoblastic leukemias oncogenic activating mutations of Notch1 have been detected and inactivation of Notch1 signaling impairs leukemia cell proliferation and promotes ap
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br Discussion Using HBV transgenic mice
2021-11-01
Discussion Using HBV transgenic mice, Kim, et al. first reported that the HBx gene caused HCC [34]. Since then, transgenic mice have become a useful experimental model for defining the molecular events of HBV hepatitis, and HBV-related hepatocarcinogenesis. In the present study, we first confirme
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br Acknowledgements br Introduction Obesity
2021-11-01
Acknowledgements Introduction Obesity is a growing pandemic, which becomes a global public health problem. The evidence has been readily available and mounting, demonstrating that obesity increases incidences of chronic comorbidities, such as non-alcoholic fatty liver diseases, diabetes, cardi
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As illustrated in among all
2021-11-01
As illustrated in , among all synthesized compounds, biphenyl derivatives , , , , and with substitutions at the 3-position possessed the best FAAH inhibitory capacity. These 5 compounds demonstrated a good activity against FAAH with IC values in a submicromolar range. Nevertheless, when replacing t
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Interestingly hSMC displayed a similar morphological respons
2021-11-01
Interestingly, hSMC displayed a similar morphological response to ET-1 as CHOETA. This dramatic lowering of normalized cell index in hSMC mimics ET-1 induced smooth muscle contraction. Earlier studies have shown that stress-fiber formations in CHOETA are mediated by Gq/PLC and G12 and in CHOETB by G
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br Acknowledgments This study was financially supported
2021-11-01
Acknowledgments This study was financially supported by National Science Center Poland grant No DEC-2011/02/A/NZ4/00031 (KKK), Jagiellonian University Medical College (Poland) grants: K/ZDS/007130 (SM) and K/ZDS/007131 (SM), COST Action CA15135 (DŁ, HS, KKK) and DFG INST 208/664-1 FUGG (HS). Than
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Based on our results we propose three
2021-11-01
Based on our results, we propose three possible mechanisms of HER2 loss after trastuzumab-based therapy (Fig. 3). The first possibility is a result of the differential effects of treatments on clonal subsets. In breast cancer, such selective pressure has been suggested to preferentially eradicate HE
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Fluorescein-12-dUTP synthesis Although in in vitro analyses
2021-10-29
Although in in vitro analyses GANT61 sensitized Daoy Fluorescein-12-dUTP synthesis to RITA treatment, this was not fully reflected in the in vivo xenograft studies in nude mice, as the combinatorial treatment elicited a comparable reduction of tumor growth. However, the dual drug administration redu
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Recently several dual GLP GIP receptor agonists have been de
2021-10-29
Recently, several dual GLP-1/GIP receptor agonists have been developed as a treatment of type II diabetes. These peptides can activate both the GLP-1 and the GIP receptor. Such dual receptor agonists are superior compared to single GLP-1 analogues such as liraglutide (Finan et al., 2013). Previously
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To date three GAL subtype receptors
2021-10-29
To date, three GAL subtype receptors have been cloned and characterized, GALR1, GALR2 and GALR3. However, it is unknown which one(s) of the three subtype receptors in BAY 61-3606 is most effective to regulate insulin resistance in diabetic rats as yet. Recent studies fromanimalmodels of diabetes an
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