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Regulation of FGF signalling is
2022-01-07
Regulation of FGF signalling is critical to ensure a balanced response to receptor stimulation. This occurs largely through negative feedback mechanisms, including receptor internalisation via ubiquitination (Wang et al., 2002) and induction of negative regulators, for example SPRY, SPRED 1 and 2 an
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Main Text FFAR GPR is a
2022-01-07
Main Text FFAR1 (GPR40) is a long-chain fatty YT Broth, 2X powder blend receptor (LCFA) receptor highly expressed and enriched in enteroendocrine cells, where it senses LCFAs generated from dietary triglycerides, and in pancreatic islet cells, where it acts as a powerful stimulator of insulin secr
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The investigation in vitro revealed that aldolase as
2022-01-07
The investigation in vitro revealed that aldolase, as well as FBPase, has affinity to α-actinin, one of the structural protein of the Z-line (Rakus et al., 2003a, Mamczur et al., 2005). Therefore, the existence of in vivo heterologous complex, consisting of aldolase, FBPase and α-actinin has been po
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In our cohort each patient had a median of Anti
2022-01-07
In our cohort, each patient had a median of 2 Anti-FXa measurements performed daily and a median of 1 infusion rate change daily to maintain therapeutic unfractionated heparin levels. Previously, several studies have documented that APTT-based protocols lead to more fluctuations in comparison with A
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br FAAH mediation of fear
2022-01-07
FAAH mediation of fear and extinction In addition to being a major target and modulator of stress, the BLA is a critical node within the neural circuitry subserving learned fear behaviors. The BLA is activated during the formation, expression, and extinction of conditioned fear memories, and dama
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apomorphine receptor Certainly the immune relevance of Hippo
2022-01-07
Certainly, the immune relevance of Hippo becomes more complicated and divergent in the vertebrates than in Drosophila. In terms of inflammation of mammalians, the stories are diversified (Fig. 2). Previously, MST1/2 has been well characterized not only as a controller of lymphocytes adhesion and mi
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Preadipocytes are capable of differentiating into lipid lade
2022-01-07
Preadipocytes are capable of differentiating into lipid-laden mature adipocytes. Lipid droplets are a prominent morphological feature of mature adipocytes, which is accumulated and maintained during adipocytes differentiation [26]. In this study, rHhip treatment increased lipid accumulation, as well
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mln4924 Three main mechanisms have been proposed
2022-01-07
Three main mechanisms have been proposed for the secretion of active forms of hedgehog ligands: first, construction of a multimeric molecule with lipid moieties placed on the inside, making a soluble Hh protein which can diffuse from the membrane; second, function of dispatched proteins through pack
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In three independent groups identified GPR
2022-01-06
In 2003, three independent groups identified GPR109A (HM74A) and GPR109B (HM74), two GPCRs, as the receptors for niacin., , GPR109A, which is present in all species, is a high affinity receptor for niacin., GPR109B, which is only present in human and chimpanzee, is a low affinity receptor for niac
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In the present study we aimed to
2022-01-06
In the present study, we aimed to investigate the effect of a common dairy and beef genetic background on the mRNA Rofecoxib of the AdipoQ system and GPR109A in different adipose depots and liver. Materials and Methods Results Comparing fat masses between families (fat-type vs. lean-type cow
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Indeed in women with different causes of epithelial
2022-01-06
Indeed, in women with different causes of epithelial layer damage, HIV infection rates have been reported to be very high [2], [3]. As observed from in vivo studies, disruption of the epithelium due to pathogens [45], [46] or chemical irritants [47], has resulted in women being at a higher risk of H
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In this study it was demonstrated that also in mice
2022-01-06
In this study it was demonstrated that also in mice chronically exposed to CS, lung inflammation persists after SC and is associated with a progressive alveolar loss and remodeling of respiratory tract, characterized by the onset of bronchial and bronchiolar GCM and peribronchiolar fibrosis. Persist
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Polyunsaturated fatty acids PUFAs represent a class of lipid
2022-01-06
Polyunsaturated fatty acids (PUFAs) represent a class of lipids that contain two or more carbon double (unsaturated) bonds (CC) and classified as n-3, n-6 and n-9 fatty acids. PUFAs including n-3 such as docosahexaenoic Camptothecin (DHA), eicosapentaenoic acid (EPA) and n-6 such as arachidonic aci
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br Conclusions Osteoclcastogenesis is regulated
2022-01-06
Conclusions Osteoclcastogenesis is regulated by multiple signal transduction pathways. To maintain bone homeostasis, osteoclast cells must achieve a balance regulation of formation, function, and trafficking of its precursors. Here, we proposed a model in which crosstalk between Fas and S1P/S1P1
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Although exhibited high inhibitory activity was found to
2022-01-06
Although exhibited high inhibitory activity, was found to be metabolically unstable due to the hydrolysis of the phosphate group (data not shown), which prompted us to modify the phosphate moiety of . Comparison of the activities between three compounds bearing no or different spacer groups (, , a
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