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br Acknowledgments br Introduction When human
2022-03-21
Acknowledgments Introduction When human red blood cell (hRBC) membranes are depolarized, either as intact Telaprevir synthesis suspended in depolarizing (low Cl−) Ringers or under voltage clamp conditions using excised inside-out patches, they respond by opening a nonselective voltage-depende
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br Results br Discussion secretase mediated proteolysis of
2022-03-21
Results Discussion γ-secretase-mediated proteolysis of integral membrane proteins is required for diverse biological processes (Lal and Caplan, 2011). One γ-secretase target of particular interest is Notch, as recent work has shown Notch activity to be increased in obesity and associated metab
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Encouraged by the observation obtained from
2022-03-21
Encouraged by the observation obtained from region A, we selected the structure of 1 as the next template to successively pursue the SAR on regions B-D of 1 (lower side of Fig. 2). Next, we turned attention to the external aromatic ring of 1 to verify the impact on the antagonistic activity and prep
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The current gold standard for diagnosing BAM or BAD is
2022-03-21
The current gold standard for diagnosing BAM or BAD is the measurement of BA turnover rate with radiolabelled tauroselcholic (75selenium) (S)-10-Hydroxycamptothecin (also known as the SeHCAT retention test). SeHCAT test involves the use of a synthetic analogue of naturally occurring conjugated taur
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br Promotion of GLS expression Glutamine metabolism is anoth
2022-03-18
Promotion of GLS2 expression Glutamine metabolism is another target for alteration in ferroptosis. Glutamine is required for the induction of ferroptosis during serum-induced injury after amino ACP-196 starvation [72]. The first step of glutamine catabolism is its conversion to glutamate, which
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The exact mechanism by which N BPs
2022-03-18
The exact mechanism by which N-BPs inhibit FPPS remains unclear. Computer modeling [10] suggests that N-BPs mimic the structure of the enzyme’s natural isoprenoid pyrophosphate substrates, geranyl pyrophosphate (GPP)/dimethylallyl pyrophosphate (DMAPP) or act as carbocation transition state analogs
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Introduction Protein tyrosine phosphorylation plays key role
2022-03-18
Introduction Protein-tyrosine phosphorylation plays key roles in a variety of intracellular signaling pathways involved in cell proliferation, differentiation, gene expression, cell adhesion, and metabolic changes [1]. While receptor-type tyrosine kinases localize to the plasma membrane, most of no
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duvelisib Drosophila is a well established model to
2022-03-18
Drosophila is a well-established model to investigate the molecular and cellular defects underlying human neurodevelopmental disorders (Oortveld et al., 2013, van der Voet et al., 2014). Here, we establish Drosophila as a model for understanding the mechanisms linking mutations in KDM5 family protei
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There were hub genes identified by WGCNA among which KIBRA
2022-03-18
There were 11 hub genes identified by WGCNA among which KIBRA was the hub gene of the black module. The bioinformatics method is an effective and powerful tool to analyze mRNA br 8 sale profiles and the related pathways. For instance, the lung cancer risk modules that were closely related to lung c
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Although HK localizes mainly to either the cytosol
2022-03-18
Although HK localizes mainly to either the cytosol or mitochondria [29], [30], [31] and cardioprotection is associated with increased mitochondrial HK binding, some studies have identified a component of HK located in intracellular vesicles within the cardiomyocyte [48], [61], supporting older data
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Recently anti tumor or antiviral strategies using RNAi for
2022-03-18
Recently, anti-tumor or antiviral strategies using RNAi for both gene silencing and innate-receptor activation were designed; one mechanism of these strategies is activating the intracellular retinoic acid–inducible gene I protein (RIG-I). 5′-Triphosphate RNA (3p-small interfering RNA [siRNA]) is th
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enolase br Conclusions br Acknowledgements The authors thank
2022-03-18
Conclusions Acknowledgements The authors thank Matt JM Wood and colleagues (AstraZeneca, UK) for permission to use logD and protein binding data presented in Sup. Table S2. Introduction The number of people suffering from type 2 diabetes mellitus (T2DM) has escalated worldwide as a consequ
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Temsirolimus Introduction Adaptations in the metabolism of c
2022-03-18
Introduction Adaptations in the metabolism of cancers contribute to tumor survival and growth and present opportunities to develop novel therapeutic strategies (Kelloff et al., 2005, Som et al., 1980). In particular, glutamine metabolism plays such an important role in cancer growth that a phenomen
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Nowadays there is no information if bifunctionality
2022-03-17
Nowadays, there is no information if bifunctionality is an exclusive trait of the order Methanococcales or if this characteristic is shared by other orders from archaea, like Methanosarcinales. These organisms are mainly methanogenic, and are not able to use exogenous hexoses as carbon source for ce
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A pooled overall survival analysis at year
2022-03-17
A pooled overall survival analysis at 1year showed no difference in survival between the two study arms, although these studies were not designed or powered to demonstrate a survival benefit. Among the 979 total patients in both ROMANA 1 and 2, about 55% continued on to the ROMANA 3 trial. That tria
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