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Splicing machinery dysfunctions have been associated to CLL
2019-05-24
Splicing machinery dysfunctions have been associated to CLL, in particular gene mutations (splicing factor 3B subunit 1) which are present in about 15% of patients . To our knowledge, no gene mutation has ever been detected in CLL. In order to broaden our knowledge on the frequency of splicing mu
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br Drug resistance In clinical
2019-05-24
Drug resistance In clinical practice, there is no cross–drug-resistance between As2O3 and RA or other antileukemic agents. This may be explained by the non-liposoluble nature of As2O3, its small molecular weight, and its distinctive modes of action [20]. In our observation, primary As2O3 resistan
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br We sincerely appreciate the comment by Lombardi
2019-05-24
We sincerely appreciate the comment by Lombardi et al on our published paper. demonstrates the incidence of dyspnea and the discontinuation of ticagrelor due to dyspnea in patients who reported dyspnea in Phase 3/4 clinical trials of acute coronary syndrome with available relevant data. Our study
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Despite the challenges since the Safe Motherhood
2019-05-23
Despite the challenges, since the Safe Motherhood Initiative was launched almost 30 years ago, international institutions such as the World Bank and WHO, and independent groups such as the Institute for Health Metrics and Evaluation, have developed, published, and continually refined estimates of ma
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br Introdu o Conste que nossa
2019-05-23
Introdução Conste que nossa percepção é que as noções de reservas, guetos, ou comunidades remanescentes, não dão conta da realidade dessas reivindicações coletivas. Portanto, experiências como as dos Estados Unidos, Haiti, Cuba, República Dominicana, entre outros países com expressivo contingente
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Adem s apoy ndose en comentarios de Luis
2019-05-23
Además, apoyándose en comentarios de Luis Mario Schneider, Mojarro complementa la historización del movimiento centrándose en Arqueles Vela, “retaguardia de la vanguardia” —debido order clemastine que Vela no firmó ninguno de los manifiestos estridentistas y era el menos visible, actuando siempre de
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br Conflict of interest br Authors contributions br Acknowle
2019-05-23
Conflict of interest Authors’ contributions Acknowledgements Introduction Aromatase-Inhibitors (AIs) are commonly used in the treatment of post-menopausal women with a history of hormone receptor-positive breast carcinoma, and have been shown to decrease bone mineral density (BMD) and in
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More recently primary tumor driven generation of a
2019-05-23
More recently, primary tumor driven generation of a bone pre-metastatic niche was observed in a mouse model of estrogen receptor-negative breast cancer metastasis. Specifically, lysyl oxidase (LOX) secreted into the circulation from hypoxic primary breast tumors disrupted bone homeostasis, thereby i
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br Interpretation of identified genetic variants and genetic
2019-05-23
Interpretation of identified genetic variants and genetic counseling Although the current expert consensus statement recommends that comprehensive or BrS1 (SCN5A) targeted BrS genetic testing can be useful for genetic testing [63], not all the published SCN5A mutations in BrS have been subjected
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Findings from the last major
2019-05-23
Findings from the last major systematic review of the global prevalence of echocardiographic rheumatic luteolin disease showed that the highest calculated regional prevalence was in sub-Saharan Africa (5·7 cases per 1000 people), indigenous people in the Pacific islands, Australia, and New Zealand
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br CONFERENCIA LATINOAMERICANA M XICO La carta
2019-05-23
CONFERENCIA LATINOAMERICANA: MÉXICO, 1961 La carta que Cárdenas le envió en diciembre de 1962 salinomycin Silva Herzog, luego de recibir y leer su libro Hispanoamérica en lucha por su independencia, se destaca por su valoración de los procesos independentistas latinoamericanos y alude a su partic
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On Aug WHO quietly released a report
2019-05-23
On Aug 23, WHO quietly released a report that should be essential reading for all. Coming 15 years after the Abuja Declaration by African governments to commit to spending 15% of annual domestic budgets on health, concludes with a stark analysis: “For every US$100 that goes into state coffers in Af
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Notwithstanding issues of equity improvement of
2019-05-23
Notwithstanding issues of equity, improvement of research capacity in LMICs has practical benefits. People working and living in LMICs are better placed to define issues of importance to their populations than are people living thousands of miles away in HICs—who often fund research based on their o
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Para refrendar su cr tica al
2019-05-22
Para refrendar su crítica al “uso descontextualizado y descontextualizante” de la noción de los ecl, Mato impulsó el cambio de nombre del Grupo de Trabajo NIBR189 “Cultura y Poder”, después de su tercera reunión en Caracas en noviembre de 2001, reunión de la cual se derivó una tercera y amplia anto
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The reduction in mother to child transmission MTCT of HIV
2019-05-22
The reduction in mother-to-child transmission (MTCT) of HIV is one of the greatest success stories of the antiretroviral therapy (ART) era. However, evidence is accumulating that, despite avoiding HIV, HIV-exposed uninfected (HEU) infants have more infectious morbidity and mortality than HIV-unexpos
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