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With respect to bone metabolism and ossification related
2019-08-28
With respect to ‘bone metabolism and ossification’-related genes, treatment of SaOS-2 osteoblast-like Hesperadin with MS-10 up-regulated IGFBP-4, TG2, and SOST. Up-regulation of IGFBP-4 in SaOS-2 cells inhibits DNA and protein synthesis induced by IGF-1 (Kudo et al., 1995, Kudo et al., 1996). In ad
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Introduction Ubiquitylation is a post translational
2019-08-28
Introduction Ubiquitylation is a post-translational modification which impacts almost every biological process in the cell. Dysregulation of the ubiquitylation pathway is associated with several diseases, including cancer, neurodegenerative disorders, and immunological dysfunctions. Single ubiquiti
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nucleoside transporters The important role of miRNAs in
2019-08-28
The important role of miRNAs in cellular differentiation has been proposed recently. Previous studies had suggested roles for different miRNAs during osteogenesis [20]. Certain miRNAs could promote osteoblast differentiation, such as miR-194 [20], whereas others could inhibit the cell differentiatio
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Mother rats acutely treated with quinpirole and mg kg
2019-08-28
Mother rats acutely treated with quinpirole (0.5 and 1.0 mg/kg) decreased the pup exploration time but increased the object exploration, so they showed a significantly lower pup preference ratio. They also showed impaired maternal performance in the home cage, consistent with our previous study (Zha
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br Conclusion In conclusion DNA methylation is
2019-08-28
Conclusion In conclusion, DNA methylation is a major epigenetic mark, which regulates temporal and spatial expression of the testicular genes required for normal spermatogenesis process. There are two types of methylation, maintenance and de novo methylation, which are catalysed by DNMT1, DNMT3A
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ABH expression is elevated in
2019-08-28
ABH3 expression is elevated in prostate carcinomas and has been referred to as prostate cancer antigen-1 or PCA-1. ABH3/PCA-1 was proposed as a diagnostic marker for prostate cancers, and suggested as a possible therapeutic target [82]. However, the recent studies of ABH2 and ABH3-null mice indicate
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nucleoside analog The results described in the present
2019-08-28
The results described in the present study confirm key restrictions on reaction conditions which must considered to maximize reactor productivity. Increased viscosity should be avoided for the amination of ketones by L-AmDH, as a 4-fold increase in viscosity can lower the reaction rate by as much a
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Similarly to the chemokine CCL the level of
2019-08-28
Similarly to the chemokine CCL-5, the level of the chemokine SDF-1 in the groups of individuals with APD did not differ from its level in the control group. However, a slight increase in the level of this chemokine was recorded in the group of women and men with APD and PTSD as compared with the cor
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To extend these toxicity minimization strategies to D
2019-08-28
To extend these toxicity minimization strategies to 3D tissues, a more complicated mass transfer model is necessary to account diffusion in the interstitial space, as well as transport across cell membranes. Until recently, tissue mass transport in cryobiology was modeled using classic spatially dep
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Mammalian cells contain significant amounts of
2019-08-27
Mammalian cells contain significant amounts of a relatively lesser known enzyme that shows marked specifity for ether lipids containing AA and other 20–22 carbon fatty acids. This enzyme is called CoA-independent transacylase (CoA-IT), and transfers polyunsaturated moieties of 20–22 carbons, typical
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Our previous work has demonstrated that two glutamate residu
2019-08-27
Our previous work has demonstrated that two glutamate residues (Glu-305 and Glu-331 in murine and human TPP II) in the active site are important for exopeptidase activity in mTPP II [17]. At least one of these, Glu-331, seems to form a salt bridge to the N-terminal amino group of the substrate, posi
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br Development of the double
2019-08-27
Development of the double strand break repair model for meiotic recombination Meiotic recombination was first described by Frans Alfons Janssens using appreciate in the salamander Batracoseps attenuatus in 1909 [21] and then further elaborated at the genetic level in Drosophila by Thomas H. Morg
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DDR is characterized by an N terminal
2019-08-27
DDR2 is characterized by an N-terminal discoidin domain and a C-terminal kinase domain [7]. Characteristics of DDR1, which is a homologue of DDR2, have been extensively investigated in terms of expression level in cancer tissues and biological functions in normal and cancer cell conditions, but cha
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The purposes of this study are
2019-08-27
The purposes of this study are to investigate the molecular function of DDR2, especially in cellular proliferation in prechondrocytes, and to examine the relationship between the proliferation and differentiation of prechondrocytes through both in vitro and in vivo analysis. Materials and methods
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Based on our studies presented
2019-08-27
Based on our studies presented above, atipamezole can be used as a new in vitro and in vivo tool nos inhibitor as a pan-CYP inhibitor for CYP mediated metabolism study. It carries many unique characteristics compared to ABT which is currently being widely used for this purpose. These new characteri
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