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CB-5083 synthesis The idea that ASB can drive compartment ex
2021-01-11
The idea that ASB11 can drive compartment expansion in the CNS is further supported by in vitro work in human neuronal precursors. Nerve growth factor (NGF)-induced differentiation of PC12 pheochromocytoma CB-5083 synthesis [11] and RA-induced human pluripotent teratocarcinoma carcinoma (NT2) cells
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Intriguingly one E residue may serve
2021-01-11
Intriguingly, one E2 residue may serve as a molecular ‘gate’ to allow the C-terminus of ubiquitin to access the closed E2~Ub conformations favorable for ubiquitin transfer. This residue, Asp87 in UbcH5 family members, resides on one side of the opening that leads to the active site Cys (Fig. 4D). In
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br Acknowledgments br Introduction to the somatic mitotic
2021-01-11
Acknowledgments Introduction to the somatic mitotic cell cycle Cell cycle dysregulation and cancer Structures of the cyclin-dependent protein kinases Structure of the CDK hydrophobic skeletons Classification of protein kinase-drug complexes Dar and Shokat defined three notch pathwa
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Three dimensional conformational changes in the cargo protei
2021-01-11
Three-dimensional conformational changes in the cargo protein’s NES, caused by protein phosphorylation, dephosphorylation, or mutation, can regulate CRM1 binding (Craig et al., 2002, Vogt et al., 2005). Additional protein modifications such as sumoylation, ubiquitination, acetylation, and/or the bin
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Flexible alignment of isopropylphenylaminobenzimidazole with
2021-01-11
Flexible alignment of 7-isopropylphenylaminobenzimidazole 16 with the lead Nepafenac 1 was performed using MOE. It was found that the aryl group of compound 16, exemplified as a yellow circle in Figure 2, overlapped well with the corresponding alkyl chain of compound 1 as well as the other key func
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br Acknowledgments br Introduction Understanding
2021-01-11
Acknowledgments Introduction Understanding the characteristics of the Amazonian Dark soils “Terras Pretas de Índio” (TPIs) is of ecological importance, because the TPI soils represent a residue-based model for tropical sustainable agriculture (Sombroek et al., 2003, Neves et al., 2003, Cohen-O
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The aim of this study was to use
2021-01-11
The aim of this study was to use molecular methods to characterise C. difficile isolates circulating in the Czech Republic from 2013 to 2015. Material and methods Discussion During a three-year period (2013–2015) a total of 32 hospitals voluntarily participated in this project, but only 11 ho
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This approach is similar to that
2021-01-11
This approach is similar to that suggested by the previous edition of the GL [6]. Not surprisingly, the questions to be answered are the same (i.e., was the event TLOC? In cases of TLOC, is this ck1 inhibitor of syncopal or non-syncopal origin? In cases of suspected syncope, is there a clear aetiolo
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It is interesting to note that our
2021-01-11
It is interesting to note that bv8 our results show a very similar behavior in binding of DDR2 ECD to immobilized a-telo (bovine-dermal) versus telo- (rat-tail) collagen I as a function of its oligomeric state. Thus, the telopeptide region of tropocollagen exerts little influence on DDR2-collagen b
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br Materials and methods br
2021-01-11
Materials and methods Results Discussion Anti-EGFR therapy for epithelial carcinomas has important clinical significance, but widespread intrinsic or acquired resistance seriously affects efficacy. Mutation and heterodimerization of EGFR are the two main causes of resistance to anti-EGFR th
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Long stretches of ssDNA have also
2021-01-09
Long stretches of ssDNA have also been observed in rad53-1 mutant 7-Ethyl-10-hydroxycamptothecin under replication stress using EM images (Sogo et al., 2002). Deletion of EXO1, a 5′-to-3′ exonuclease, can suppress the generation of ssDNA detected in rad53-1 mutant cells (Cotta-Ramusino et al., 2005)
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Introduction Psoralea corylifolia L Leguminosae is a well kn
2021-01-09
Introduction Psoralea corylifolia L. (Leguminosae) is a well-known traditional Chinese medicine, and it has been widely used for the treatment of various diseases like bronchial asthma, leucopenia, vitiligo and psoriasis in East Asian countries (Zhang et al., 1990). Previous studies have reported t
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br Materials and Methods br Results br Discussion HSCs
2021-01-09
Materials and Methods Results Discussion HSCs have been identified as major collagen-producing Hoechst 34580 in the injured liver (1), and activation of HSCs has become the central link for liver fibrosis (2). The factors that regulate the biological behavior of HSCs include soluble regula
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In these tables the AAD for
2021-01-09
In these tables, the AAD for most of the alcohols in 2B and 3B schemes is less than 1%. It should also be said that for ethanol, AAD in 2B scheme is (0.36%) and for 3B scheme it is (0.02%), which indicates superior prediction of 3B scheme compared to 2B in CPA ƒ-theory model. Table 8a, Table 9 show
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Introduction Piperine is a pungent alkaloid and accounts
2021-01-09
Introduction Piperine is a pungent alkaloid and accounts for 2–5% dry weight in black and white peppers (Butt et al., 2013). Physiological benefits of piperine have been a subject of extensive research in recent years. Piperine is an antioxidant with strong anti-inflammatory and antiangiogenic acti
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