• In present study we measured the methylation and expression

  2021-02-16

  

  In present study, we measured the methylation and monohydrochloride levels of CDKL2 in HCC tissues and cell lines. Meanwhile, correlations between the methylation and mRNA expression, clinicopathological features were evaluated. Materials and methods Results Discussion DNA methylation is

• The use of AACSB accreditation as an indicator of expected

  2021-02-16

  

  The use of AACSB accreditation as an indicator of expected performance on the CPA exam has been examined by prior studies (e.g. Barilla et al., 2008, Boone et al., 2006, Grant et al., 2002, Howell and Heshizer, 2006, Lindsay and Campbell, 2003, Marts et al., 1998). While these studies are based on

• The repeat sequence TTAGGG of telomere

  2021-02-15

  

  The repeat sequence “TTAGGG” of telomere could be directly recognized by TERF1. TERF1 is indispensable for the maintenance of telomere acamprosate calcium receptor structure and integrity (Tan et al., 2017). Trf1 genetic depletion in vivo induces a persistent DNA damage response and telomere uncappi

• Before addressing point by point the aforementioned topics i

  2021-02-15

  

  Before addressing point-by-point the aforementioned topics in separate sub-sections it should be remarked that the strength of recommendations provided by guidelines is graded in three classes: I (evidence and/or general agreement that a given treatment or procedure is beneficial, useful,effective),

• Upon assembly of HLA tetramers loaded with

  2021-02-15

  

  Upon assembly of HLA tetramers loaded with either of the two peptide versions, we could query the T cell repertoires of RA subjects and healthy individuals for the presence of cognate T Pralatrexate receptor recognizing the respective peptide-HLA complexes. We found no significant difference in fre

• Nimodipine is an L type calcium channel antagonist that

  2021-02-12

  

  Nimodipine is an L-type calcium channel antagonist that reduces excessive calcium influx during pathological conditions, contributing to its neuroprotective properties (Zornow and Prough, 1996; Kobayashi and Mori, 1998). Autophagy can be induced by increased [Ca2+] (Rami et al., 2008). Nimodipine si

• br Guidance of B cell localization by EBI br EBI

  2021-02-12

  

  Guidance of B cell localization by EBI2 EBI2 expression and B cell disease Although chemoattractant receptors of the GPR family play essential roles in coordinating the migration of lymphocytes for efficient responses against pathogens, their dysregulation can result in the initiation or progr

• In an effort to discover additional GPCRs directing

  2021-02-12

  

  In an effort to discover additional GPCRs directing the migratory events of responding B cells, we identified Epstein-Barr virus (EBV)-induced gene 2 (EBI2) as a promising candidate. The gene encoding EBI2 (Ebi2, also known as Gpr183) was originally identified together with Ebi1 (Ccr7) as the most h

• There are numerous resources clinicians

  2021-02-11

  

  There are numerous resources clinicians may use to gather information on the strength of evidence related to pharmacogenetic-based dosing and treatment decisions, as well as specific dosing guidelines, some of which are summarized in this review. These include resources from CPIC, which provides pee

• As discussed in the introduction

  2021-02-11

  

  As discussed in the introduction, many pregnant women take medications such as nifedipine and indinavir, which are considerably metabolized by CYP3A [26]. Previous reports have also shown increased CYP3A activity following pregnancy [7], [9], which is consistent with our results. However, previous s

• br Acknowledgements br Introduction Chemokines are a superfa

  2021-02-11

  

  Acknowledgements Introduction Chemokines are a superfamily of chemotactic cytokines that play important roles in regulating cell migration and activation under inflammatory conditions (Nomiyama et al., 2008; Peatman and Liu, 2007; Zlotnik and Yoshie, 2000), such as angiogenesis (Arenberg et al

• br Acknowledgments This work was

  2021-02-11

  

  Acknowledgments This work was funded by the EU ERDF and the Spanish Ministry of Economy and Competitiveness (MINECO) under Project TIN2013-41576-R, and the Spanish Ministry of Education, Culture and Sport (MECD) under a FPU grant (AP2010-3259), and the Andalusian Regional Government (Spain) under

• Cx platin could improve the level of cellular uptake

  2021-02-11

  

  Cx-platin could improve the level of cellular uptake and DNA platination, hence triggering distinct DNA damage repair pathways. The data (Fig. 3B, C and D) demonstrated that Cx-platin could increase the foci number of γH2AX in cancer cells, preventing the efficient DSBs repair. This gives a good exp

• Programmed cell death via apoptosis is associated with a ser

  2021-02-11

  

  Programmed cell death via apoptosis is associated with a series of morphological and biochemical characteristics, including cell shrinkage, the rapid increase of intracellular calcium, nuclear condensation, DNA fragmentation and the formation of apoptotic bodies. Known as a shared feature of most ap

• br Materials and methods br Results br Discussion

  2021-02-11

  

  Materials and methods Results Discussion In this study, the N&B analysis showed new evidence regarding the proportion and the oligomerization state of the AT1 and the ETA receptors near or on the plasma membrane. Althought, preliminary studies suggest that the AT1 and the ETA receptors occu

15131 records 671/1009 page Previous Next First page 上5页 671672673674675 下5页 Last page