Archives
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Alzheimer s disease AD is a chronic progressive
2021-01-15
Alzheimer’s disease (AD) is a chronic, progressive neurodegenerative disorder of the BMS-303141 which is considered a leading cause of dementia and affects 20–30 million people worldwide. Presently, a suitable treatment and prevention strategy against AD is hardly available. Various studies have be
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We found all cases to show
2021-01-15
We found all cases to show at least some IGF-1R expression by immunohistochemistry. This is consistent with its ubiquity at the mRNA or protein level in ES/PNET cell lines or clinical samples as shown by others.12, 14 Evidence that IGF-1R expression is required for EWS-FLI1 transformation of mouse f
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Recent advances in microarray and next generation sequencing
2021-01-15
Recent advances in microarray [32] and next-generation sequencing [33] based technologies have led to tremendous increases in information about the molecular mechanisms that are responsible for malignant transformation of rare and poorly understood soft tissue sarcomas. However, data interpretation
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We have previously shown that sustained pCPT treatment
2021-01-15
We have previously shown that sustained 8-pCPT treatment favored Ca2+-dependent arrhythmogenic activity in rat ventricular cardiomyocytes [8]. Fig. 2 shows line-scan Ca2+ images of myocyte incubated without (Fig. 2A left) and with 8-pCPT (Fig. 2A right) subjected to a train of electrical stimulation
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The action of pt PGE
2021-01-15
The action of 17-pt-PGE2 as an EP1 receptor agonist [34] was demonstrated in several experimental settings, including cancer, neurons, vascular system, kidney and was confirmed by application of EP1 receptor selective antagonists [35], [36], [37], [38], [39], [40], [41]. Receptor binding studies in
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A robust meta analysis of randomized
2021-01-15
A robust meta-analysis of 22 randomized clinical trials found that application of ischemic preconditioning strategies reduce ventricular arrhythmias [3]. Additionally, it was demonstrated that remote ischemic perconditioning (perRIC) induces immediate cardioprotection during ongoing ischemia by atte
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br Roles of DDR in epithelial cell differentiation
2021-01-15
Roles of DDR1 in epithelial cell differentiation Roles of DDR1 in cell migration, and invasion Dichotomous functions of DDR1 in disease progression Conclusions and perspectives The switch in a good thing from DDR1 to DDR2 during EMT is another important issue. The DDRs may exert distinc
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Judging from the densitometric analysis of the Western blots
2021-01-15
Judging from the densitometric analysis of the Western blots, CYP2E1 protein was expressed, although at very low levels, by PT cells. This corresponds to previous observations [10], showing that CYP2E1 was expressed in the PT, although expression was higher in the distal tubule. Testosterone 6β-hyd
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br Experimental Procedures br Acknowledgments
2021-01-15
Experimental Procedures Acknowledgments We thank R. Brink for providing HEL2x, M. Tanaka for CD169DTR mice, R. Lathe for making Cyp7b1+/− mice available, and M. Barnes and A. Reboldi for comments on the manuscript. T.Y. is an Irvington Institute Postdoctoral Fellow at the Cancer Research Insti
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The CysLT receptor antagonist BayCysLT RA significantly supp
2021-01-15
The CysLT2 receptor antagonist BayCysLT2RA significantly suppressed multiple antigen challenge-induced infiltration of eosinophils and mononuclear Telatinib mg into the lung, indicating that CysLT2 receptor activation is involved in leukocyte migration. In contrast to the present finding, Barret et
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Interestingly ASV infusion in the
2021-01-15
Interestingly, ASV-30 infusion in the dRN of saline pre-treated rats had no effect on anxiety-like behaviors. This result may be due to the saline pre-treated group exhibiting relatively low levels of anxiety-like behaviors (when compared to saline pre-treated rat of the first experiment that were n
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To determine the time course
2021-01-15
To determine the time course of ZD2767P+CPG2 DNA–DNA interstrand cross-link formation, HT29 and LS174T colorectal tumour fauc were exposed to the drug for 10, 30 or 60 min. The levels of DNA interstrand cross-links in HT29 or LS174T cells did not increase with exposure time, suggesting that ZD2767P
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The role of Epac in the regulation
2021-01-14
The role of Epac in the regulation of intracellular Ca homeostasis and contractility is still matter of debate. In rat adult cardiomyocytes, acute Epac stimulation decreased the amplitude of Ca transients [6], [9], [10] with either no changes [6] or increments [9] in cell shortening, suggesting an e
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We also observed reduced insulinotropic effects after intrav
2021-01-14
We also observed reduced insulinotropic effects after intravenous administration of both GLP-1 and GIP with atropine, whereas no inhibition was observed by atropine of the direct effects of GLP-1 and GIP action on beta-cells in the islet experiments. This suggests that the reduction in circulating i
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br Conclusion br Competing interests br
2021-01-14
Conclusion Competing interests Authors' contributions Acknowledgements The work was supported by Aurigene Discovery Technologies (M) Sdn. Bhd., Industrial Doctoral Program sponsorship by Ministry of Higher Education, Malaysia and research grants by the University of Malaya, grant number