Archives
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Atglistatin br Acknowledgments This study was supported by g
2020-08-08
Acknowledgments This study was supported by grants from the Spanish Ministry of Economy and CompetitivenessPI10/00387, PI12/01087, PI12/01703, IPT-2011-0817-010000, and RIC Red de Investigación Cardiovascular (RIC)RD12/0042/0055. RIC is an initiative of Instituto de Salud Carlos III (ISCIII), Spa
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br Experimental br Results br
2020-08-08
Experimental Results Discussion In the last two decades, several studies have shown an important role for progestogens, and in particular ALLO, in the modulation of Schwann cell physiology, regulating several biochemical and functional parameters. The classical PR has been found both in rat
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br ET Antagonist for the Future
2020-08-08
ET Antagonist for the Future: Macitentan and Atresentan Macitentan is an insurmountable antagonist, resulting from structure-activity studies to improve the efficacy and tolerability of bosentan, and gained approval in the United States in 2013 for the treatment of PAH. Actelion describes the com
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br Results br Discussion In this study we
2020-08-06
Results Discussion In this study, we elucidate how cell-secreted, soluble ECDs of DDR1 and DDR2 inhibit collagen fibrillogenesis and enhance matrix mineralization for ECM endogenously generated by the cells. Using similar experimental approaches, in our earlier work we had demonstrated that ki
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DNA Damage DNA Repair Library The leukotrienes are a group o
2020-08-06
The leukotrienes are a group of major pro-inflammatory lipid mediators derived from the lipoxygenase pathway of the arachidonic DNA Damage DNA Repair Library metabolism and were so named, because of the salient feature that they can be produced by leukocytes and they have a common conjugated triene
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NVP-BGJ398 phosphate receptor br Materials and methods br Re
2020-08-06
Materials and methods Results These methods were validated according to U.S Food and Drug Administration guidelines for bioanalytical methods validation [38]. All probe-drugs tested in our CYP450 cocktail were evaluated for selectivity, sensitivity, linearity, precision, accuracy, recovery, ma
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Several studies have shown a high degree of
2020-08-06
Several studies have shown a high degree of sequence conservation especially in the nucleic Polymyxin B sulfate binding domain, usually referred to as `cold shock domain or CSD,\' highlighting the importance of the metabolic processes regulated by Y-box proteins , , , , . A direct role for YB-1 in c
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Our data suggest that VEGF A
2020-08-06
Our data suggest that VEGF-A inhibits venous identity in adult EC, recapitulating the change seen during vein graft AdipoRon in vivo. Vein graft adaptation to the arterial environment may depend on the plasticity of adult EC, and their ability to integrate VEGF signaling pathways, to properly modif
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niclosamide A number of studies have been
2020-08-05
A number of studies have been carried out to understand lipid production pathways and to increase TAGs level in higher plants. Overexpression of key niclosamide of the Kennedy pathway until now is by far the most successful strategy to increase TAG lipid content in Brassica napus, Arabidopsis thali
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DHT is generated from testosterone by
2020-08-05
DHT is generated from testosterone by SRD5A1 [14]. Rat immature Leydig BMX-IN-1 are a good model for investigating the effects of GOS on DHT production. Rat immature Leydig cells contain DHT synthetic enzyme SRD5A1 (encoded by Srd5a1) [15,16] and metabolizing enzymes 3α-hydroxysteroid dehydrogenase
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Methylcobalamin receptor The growth of macrophages from
2020-08-05
The growth of macrophages from bone marrow Methylcobalamin receptor using recombinant CSF-1 has been described previously for human, mouse, chicken and pig bone marrow cells [7], [17], [50], [52], [53], [54]. Culture of feline macrophages is a valuable tool to allow the in vitro study of the effect
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To assess the involvement of the
2020-08-05
To assess the involvement of the hydrocarbon chain of C75-CoA positioning in the acyl group binding pocket, we carried out C75-CoA inhibitory experiments with the new mutated protein, CrAT D356A/M564G. This protein has a deep clofibrate pocket for the binding of long-chain instead of short-chain acy
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In mammals COMT is present
2020-08-05
In mammals, COMT is present in two molecular forms: a soluble cytoplasmic form (S-COMT) and a membrane protein (MB-COMT) with similar kinetic mechanism. The main difference is the lower Michaelis constant (K) value for MB-COMT for catecholamines and higher maximum reaction rate (V) for S-COMT from
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ESC originally appeared to be unique among PcG
2020-08-05
ESC originally appeared to be unique among PcG proteins in being required predominantly during early embryogenesis. Temperature shift experiments with a temperature-sensitive esc allele suggested that esc is required only during early embryogenesis (Struhl and Brower, 1982) and similar experiments w
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br BP targets Two distinct BP targets namely
2020-08-05
BP targets Two distinct BP targets, namely 140/90mmHg in low-moderate risk hypertensives and different clinical characteristics: low-moderate cardiovascular risk (class I, level B), Cryptochlorogenic acid synthesis (class I, level A), previous stroke or ischemic transient attack, coronary heart