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br Halogenases Enzymatic C H
2020-01-29
Halogenases Enzymatic C–H activation leading to halogenation is another emerging area in biocatalysis [55,56]. Incorporation of halogen atoms during medicinal chemistry eff ;orts is a well-established practice, presenting an effective means to control the molecule’s bioactivity and physicochemical
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In the previous study glutamyl endopeptidase of B
2020-01-29
In the previous study glutamyl endopeptidase of B. intermedius has been reported to be distributed in the corticotropin releasing factor of B. intermedius as follows: 90% of synthesized enzyme has been detected in the culture liquid, 9.3% of glutamyl endopeptidase—in the fraction of membrane protei
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gpr120 agonist Mouse Cyp a is a homologous
2020-01-29
Mouse Cyp3a11 is a homologous isoform of the human CYP3A4 gene, and both are highly expressed in the liver (Hart, Cui, Klaassen, & Zhong, 2009). CYP3A4 is the most abundant CYP450 in hepatic microsomes responsible for drug and xenobiotic metabolism (Zanger & Schwab, 2013), and it is the most active
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br Author Contributions Statement br Conflicts of interest
2020-01-29
Author Contributions Statement Conflicts of interest Acknowledgments We thank T. Ishii, H. Inaba, and S. Nakamura (Department of Cell Biology, TMDU) for kindly gifting BACCS and technical assistance; S. Kaneko, Y. Ishida, and R. Usumi (Department of Orthodontic Science, TMDU) for experiment
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These evidence prompted us to investigate the effectiveness
2020-01-29
These evidence prompted us to investigate the effectiveness of CT-133, a newly discovered, well-tolerated, selective and potent CRTH2 antagonist, as a treatment of ALI. CT-133 has shown a potential response in treating chronic obstructive pulmonary disease (COPD), allergic rhinitis and Lubiprostone
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Elacridar Various domains of the HSA molecule have also been
2020-01-29
Various domains of the HSA molecule have also been used to make bioconjugates with increased stability, better targeting properties, and/or extended half-lives in blood. For example, domain I of HSA has been used in the preparation of antibody conjugates. This was achieved through the use of a cyclo
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Previously we have shown that complexes of protein
2020-01-29
Previously, we have shown that complexes of protein PKs with inhibitors that comprised sulfur or selenium atoms in aromatic structures were phosphorescent at room temperature, while the long-lifetime signal emitted by the free inhibitor was negligible.34, 35, 36 This phenomenon was caused by stabili
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Determination of relative potency EC by
2020-01-29
Determination of relative potency (EC50) by dose response assays in vitro is subject to the same sources of variability as determination of affinity, since the EC50 and Hill slope of the dose response curve are highly dependent on the binding of ligand to a competing receptor that may be present, an
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The nitrophenols b d were prepared as described in
2020-01-29
The nitrophenols 34b–d were prepared as described in Scheme 3b. Nitration of phenols 39b–d with 1equiv of sodium nitrate in the presence of hydrochloric 50014 mg gave an inseparable mixture of 34b–d and 40b–d (1:1). This synthetic problem was successfully avoided as described below. Nitration of 39
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br Activity based probes br
2020-01-29
Activity-based probes Characterization of coronavirus-encoded DUBs with activity-based probes To study the activity of specific DUBs, investigators frequently take advantage of the ~10kDa (monoUb or Ubl ABP) or ~20kDa (DiUb ABP) increase in MW on probe labeling. SDS-PAGE analysis or blotting f
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Given the fact that most
2020-01-29
Given the fact that most criticism on genetic association studies is the lack of replicability (Hirschhorn, Lohmueller, Byrne, & Hirschhorn, 2002), the aim of the present study is to investigate the influence of the DBH polymorphism rs1611115 (C-970T) on RD in two independent samples of healthy part
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br Acknowledgement br Introduction Human dihydroorotate dehy
2020-01-29
Acknowledgement Introduction Human dihydroorotate dehydrogenase (hDHODH), a flavin-dependent mitochondrial enzyme involved in de novo AZD1152-HQPA biosynthesis, is a validated therapeutic target for the treatment of autoimmune diseases such as rheumatoid arthritis and cancer [1], [2], [3]. Le
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Despite its significance in tumor suppression
2020-01-29
Despite its significance in tumor suppression, the molecular mechanism by which DAPK is regulated and its interplay with other tumor suppressors and oncoproteins have not been completely unraveled. Although primarily regulated by CaM binding (Cohen et al., 1997), DAPK activity can also be modulated
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Several reports by us and others have
2020-01-25
Several reports by us and others have highlighted that dimerization or oligomerization of DDR1 ECD and DDR2 ECD enhances their binding to triple-helical collagen.18, 19, 22, 28, 29, 30, 31 The ECD of DDRs consists of a discoidin domain and a stalk region. It has been reported that independent 4-ethy
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Introduction Klebsiella pneumoniae a Gram negative
2020-01-25
Introduction Klebsiella pneumoniae, a Gram-negative enteric bacterium, is an organism with significance in both biomedicine and biotechnology. Some of the strains of K. pneumoniae are opportunistic pathogens, which can cause suppurative infection, pneumoniae and urinary tract infection in humans (B