Archives
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br Materials and methods br Results br Discussion
2021-11-29
Materials and methods Results Discussion The roles of EZH2 during oocyte maturation, early embryogenesis, and somatic cell nucleus transfer (SCNT) have been studied extensively in mouse [12,30]. How it functions during porcine preimplantation development, especially the maternal effect, how
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TGR is a class A
2021-11-29
TGR5 is a class A GPCR, transducing signal through Gs-protein mediated cAMP accumulation, and was recently reclassified as the founder member of the bile–acid receptor subclass of GPCRs [22]. The cAMP-mediated signaling of TGR5 activation has been implicated in a range of cellular physiological acti
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br Conclusion In summary a series of novel GPR agonists
2021-11-26
Conclusion In summary, a series of novel GPR40 agonists bearing phenylpropiolic 20187 motif with favorable metabolic stability were prepared and evaluated for their activities as GPR40 agonists. Among them, compound 9 was identified as a structurally distinct GPR40 agonist possessing potent acti
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The bioconversion of inositol from glucose was anticipated n
2021-11-26
The bioconversion of inositol from glucose was anticipated nearly a century ago and later confirmed by isotope tracing methods [[22], [23]]. This biosynthesis of inositol involves three sequentially acting enzymes: Firstly, ATP-dependent glucokinase converts glucose to glucose-6-phosphate (G-6P) [[2
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br Materials and methods br
2021-11-26
Materials and methods Results Discussion It is known that MAPKs and Akt signaling can regulate cell migration [[24], [25], [26]]. In this study we found that dTAT-WKYMVm stimulates ERK, p38 and Akt phosphorylation in naïve CD4 T cell (Fig. 3A). However their activation did not affect naïve
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br Clinical development of FGFR inhibitors in
2021-11-26
Clinical development of FGFR inhibitors in breast cancer The rationale to explore the role of FGFR inhibitors in patients with breast cancer comes from a variety of sources. These include genomic aberrations frequently identified in the FGF/FGFR pathway in breast cancer, the increased sensitivity
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alcohol inhibitor Sumoylation of transcription factors has b
2021-11-26
Sumoylation of transcription factors has been generally linked to transcriptional repression and, in a few cases, to transcriptional activation [60] Accumulating evidence implies that corepressor complex subunits, including CoREST, CtBP, Daxx, NCoR1, SMRT and histone deacetylase complexes (HDACs), p
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Recent efforts have also tried to identify cancer subsets th
2021-11-26
Recent efforts have also tried to identify cancer subsets that are exquisitely responsive to EZH2i apart from those bearing EZH2 gene mutation (Knutson et al., 2012). The dysfunction of SWI-SNF complex, a chromatin-remodeling regulator that partially antagonizes the catalytic function of PRC2 comple
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Introduction Human immunodeficiency virus HIV persue to be
2021-11-26
Introduction Human immunodeficiency 6-MP (HIV) persue to be a major global public health problem (Joint United Nations Programme on HIV/AIDS, 2018). Globally, 36.9 million (range, 31.1 million–43.9 million) people were living with HIV in 2017 (UNAIDS, 2018a). The burden of the epidemic varies cons
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br Results br Discussion The present findings outline a
2021-11-26
Results Discussion The present findings outline a novel regulatory mechanism for fasting-induced ketogenesis, which involves histamine release from mast GSK343 into the hepatic portal system, H1 receptor-mediated stimulation of liver OEA biosynthesis, and recruitment of the nuclear receptor P
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The GPR receptor is also emerging as
2021-11-26
The GPR55 receptor is also emerging as an important therapeutic target. GPR55−/− mice possess no overt phenotype, but were protected in models of inflammatory and neuropathic pain (Staton et al., 2008). Staton et al. (2008) reported that no GPR55 mRNA could be detected by RT-PCR in the animals. Also
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Our supF forward mutation assay revealed for the first time
2021-11-25
Our supF forward mutation assay revealed, for the first time, that 5OHU predominantly induced the C→T mutation in human cells. The mechanism underlying the induction of the C→T mutation in human cells by 5OHU remains unclear, however, the finding that 5OHU predominantly induced the C→T mutation was
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AZD2858 receptor To maintain low Glu concentrations in the s
2021-11-25
To maintain low Glu concentrations in the synaptic cleft below the affinity of its receptors, this amino AZD2858 receptor is rapidly removed from the extracellular space by a family of sodium-dependent high-affinity transport systems located mainly in the plasma membrane of perisynaptic astrocytes,
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br Materials and methods Rat
2021-11-25
Materials and methods Rat forebrains were obtained from Sprague–Dawley rats at 2, 7, 14, 21, and 30–35 postnatal days and were homogenized in 1:5 volumes (w/v) of 0.32 M sucrose containing 1 mM EGTA, 1 mM EDTA, 1 μg/ml TPCK, 50 μM leupeptin, and 3 μM antipain with 10 strokes in a glass-teflon hom
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In order to test the influence of
2021-11-25
In order to test the influence of the initial depolarization, experiments were performed, where the degree of chloride substitution was varied, either by adding n-Ringer to Caspase-9 Colorimetric Assay Kit incubated in a sucrose Ringer or by suspending the cells directly in Ringers identical to th